Author/Authors :
Singh، نويسنده , , Parvinder Pal and Qazi، نويسنده , , Naveed Ahmed and Shafi، نويسنده , , Syed and Reddy، نويسنده , , D. Mahendhar and Banday، نويسنده , , Abid H. and Reddy، نويسنده , , P. Bhaskar and Suri، نويسنده , , K.A. and Gupta، نويسنده , , B.D. and Satti، نويسنده , , N.K. and Wakhloo، نويسنده , , Basant P. and Kumar، نويسنده , , H.M. Sampath and Qazi، نويسنده , , G.N.، نويسنده ,
Abstract :
Lipase catalyzed regio-selective acylation of five iridoid glycosides viz., picroside I&II, catalpol, agnuside and negundoside in the presence of various acyl donors such as vinyl acetate and p-nitrophenyl alkanoates was studied. The regio-selectivity of enzymatic acylation and yields were found to vary amongst different substrates. Monoacylated products were isolated with all the substrates under scrutiny indicating high regio-selective nature of such transformations. A series of acyl esters of picroside-I, picroside-II, catalpol, agnuside and negundoside have been synthesized by this enzymatic trans-esterification methodology.
Keywords :
Iridoid glycoside , Lipase , p-Nitrophenyl alkanoate , Trans-esterification
