One-pot chemoenzymatic synthesis of chiral disubstituted 1,2,3-triazoles in aqueous media

A one-pot, two-step procedure combining 1,3-dipolar cycloaddition and an enantioselective reduction mediated by Daucus carota (carrot root) is described. The synthesis was accomplished by first employing the biocatalyst followed by a “click” reaction under very mild conditions to yield the corresponding chiral disubstituted 1,2,3-triazoles.