Monodisperse hydrophilic polymer microspheres having carboxylic acid groups prepared by distillation precipitation polymerization

Monodisperse hydrophilic polymer microspheres having carboxyl acid group with spherical shape in the range of 160 nm and 1.52 μm were prepared by distillation copolymerizations of (meth)acrylic acid with either ethyleneglycol dimethacrylate (EGDMA) or divinylbenzene (DVB) as crosslinker. Polymerization was carried out with 2,2′-azobisisobutyronitrile (AIBN) as initiator in neat acetonitrile without stirring. The polymer microspheres were formed and precipitated out from the reaction medium during the distillation of the solvent from the reaction system through an entropic precipitation polymerization manner. The effects of the crosslinker degree on the morphology and the loading capacity of the carboxylic acid group of the resultant polymer microspheres were investigated. The growth procedures of poly(DVB-co-AA) microspheres were traced by SEM characterization. The steric stabilization through the pendent chains and surface gel and the electrostatic repulsion from the carboxyl acid groups contribute to the formation of monodisperse polymer microspheres.