Design of responsive double-hydrophilic A-b-(B-co-C) diblock terpolymers with tunable thermosensitivity

Double-hydrophilic poly[(oligo(ethylene glycol) methacrylate)-co-methyl methacrylate]-b-poly(2-(diethylamino)ethyl methacrylate), P(EGMA-co-MMA)-b-PDEA, diblock terpolymers were designed and explored in aqueous media. Thanks to the thermosensitivity of the P(EGMA-co-MMA) statistical block and the pH sensitivity of the PDEA block, these terpolymers form two distinct micellar self-assemblies at different conditions of pH and temperature. The thermosensitivity of these terpolymers can be tuned by controlling the LCST of the statistical block through its monomer unit composition.