A novel carrier of radionuclide based on surface modified poly(lactide-co-glycolide) nanofibrous membrane

Electrospun nanofibrous membrane is an approved drug carrier. However, the radionuclide carrier used an electrospun membrane is rare. In this study, Poly(lactide-co-glycolide)(PLGA) nanofibrous nonwovens were prepared through electrospinning technology, and then surface modification of the nonwoven was performed to stably conjugate the radioisotope with the fibrous membrane. A novel PLGA nanofibrous nonwoven conjugated with radioactive yttrium 90Y for tumor internal radiotherapy was prepared for the first time. Evaluation of the stability of the radioisotope indicated that the leakage of 90Y from the PLGA membranes can be neglected after 24 h incubation in saline. The retention of 90Y on the PLGA membrane was 75% when five half lives of 90Y expired and the vast majority of radioactive decay had occurred. This labeled nanofibrous membrane function as a novel radio-medical appliance with excellent surface hydrophilic and mechanical properties that can be directly implanted into the lesions not only to locally kill the cancerous cells but also to play the anti-adhesion role at where surgical procedures have been made to remove the tumor tissue.