Author/Authors :
Razakandrainibe، نويسنده , , Romy and Thonier، نويسنده , , Vincent and Ratsimbasoa، نويسنده , , Arsène and Rakotomalala، نويسنده , , Emma and Ravaoarisoa، نويسنده , , Elisabeth and Raherinjafy، نويسنده , , Rogelin and Andrianantenaina، نويسنده , , Herilalaina and Voahanginirina، نويسنده , , Odette and Rahasana، نويسنده , , Tiana Eugénie and Carod، نويسنده , , Jean François and Domarle، نويسنده , , Olivier and Menard، نويسنده , , Didier، نويسنده ,
Abstract :
The aim of this study was to provide baseline information of the epidemiological situation of malaria in Madagascar using serological markers. We carried out cross-sectional studies in schoolchildren from eight sites in the four different malarious epidemiological strata of Madagascar. We studied the prevalence of anti-MSP1 antibodies to assess the burden, and anti-CSP antibodies to estimate the transmission intensity, of malaria. The overall prevalence of each antibody tested was 46.1% for anti-PfMSP-1, 15.2% for anti-PvMSP-1, 14.9% for anti-PfCSP, 4.9% for anti-PvCSP and 2.4% for anti-PmCSP. The prevalence of the five antibodies varied significantly between the sites (P < 10−6). We also found significant effects of ethnic origin on the prevalence of anti-PfMSP1 antibodies. With regular testing in the same target populations, this data will be particularly useful for managing the elimination strategy supported by the Malagasy Government.
Keywords :
P. falciparum , P. vivax , ethnic group , P. malariae , control strategies , Madagascar , malaria , antibody , Circumsporozoite protein , Merozoite surface protein-1
