Title of article :
Benznidazole prevents endothelial damage in an experimental model of Chagas disease
Author/Authors :
Molina-Berrيos، نويسنده , , Alfredo and Campos-Estrada، نويسنده , , Carolina and Lapier، نويسنده , , Michel and Duaso، نويسنده , , Juan and Kemmerling، نويسنده , , Ulrike and Galanti، نويسنده , , Norbel and Leiva، نويسنده , , Mario B. Ferreira، نويسنده , , Jorge and Lَpez-Muٌoz، نويسنده , , Rodrigo and Maya، نويسنده , , Juan Diego، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
8
From page :
6
To page :
13
Abstract :
AbstractObjectives luate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. s (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice infected with Trypanosoma cruzi during the early phases of the infection. The effects of the treatments were assessed at 24 and 90 days postinfection by evaluating the parasitaemia, mortality, histopathological changes and expression of ICAM in the cardiac tissue. The blood levels of thromboxane A2, soluble ICAM and E-selectin were also measured. T. cruzi clearance was assessed by the detection of parasite DNA in the heart tissue of infected mice. s dazole decreased the cardiac damage induced by the parasite, and amastigote nests disappeared at 90 days postinfection. Both doses cleared the parasite from the cardiac tissue at 24 and 90 days postinfection. In addition, benznidazole decreased the thromboxane levels and normalized the plasma sICAM and sE-selectin levels by 90 days postinfection. sions administration of benznidazole at a dose as low as 30 mg/kg eradicates T. cruzi from cardiac tissue. Additionally, benznidazole prevents cardiac damage and modulates endothelial activation as part of its antichagasic activity.
Keywords :
Chronic Chagas cardiomyopathy , Thromboxane A2 , Endothelial adhesion molecules , Soluble E-selectin , Trypanosoma cruzi
Journal title :
Acta Tropica
Serial Year :
2013
Journal title :
Acta Tropica
Record number :
1742097
Link To Document :
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