Author/Authors :
Landgrebe، نويسنده , , Michael and Azevedo، نويسنده , , Andréia and Baguley، نويسنده , , David and Bauer، نويسنده , , Carol and Cacace، نويسنده , , Anthony and Coelho، نويسنده , , Claudia and Dornhoffer، نويسنده , , John and Figueiredo، نويسنده , , Ricardo and Flor، نويسنده , , Herta and Hajak، نويسنده , , Goeran and van de Heyning، نويسنده , , Paul and Hiller، نويسنده , , Wolfgang and Khedr، نويسنده , , Eman and Kleinjung، نويسنده , , Tobias and Koller، نويسنده , , Michael and Lainez، نويسنده , , Jose Miguel and Londero، نويسنده , , Alain J. Martin، نويسنده , , William H. and Mennemeier، نويسنده , , Mark and Piccirillo، نويسنده , , Jay and De Ridder، نويسنده , , Dirk and Rupprecht، نويسنده , , Rainer and Searchfield، نويسنده , , Grant and Vanneste، نويسنده , , Sven and Zeman، نويسنده , , Florian and Langguth، نويسنده , , Berthold، نويسنده ,
Abstract :
Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison between studies. Here, we discuss our view of the most important aspects of trial design in clinical studies in tinnitus and make suggestions for an international methodological standard in tinnitus trials. We hope that the proposed methodological standard will stimulate scientific discussion and will help to improve the quality of trials in tinnitus.
