Author/Authors :
Son، نويسنده , , Tae Il and Sakuragi، نويسنده , , Makoto and Takahashi، نويسنده , , Sawa and Obuse، نويسنده , , Sei and Kang، نويسنده , , Jeonghwa and Fujishiro، نويسنده , , Masako and Matsushita، نويسنده , , Haruhiko and Gong، نويسنده , , Jiansheng and Shimizu، نويسنده , , Shigeru and Tajima، نويسنده , , Yusuke and Yoshida، نويسنده , , Yasuhiro and Suzuki، نويسنده , , Kazuomi and Yamamoto، نويسنده , , Toshio and Nakamura، نويسنده , , Mariko and Ito، نويسنده , , Yoshihiro، نويسنده ,
Abstract :
A novel visible light-crosslinkable porcine gelatin was prepared for gelation and micropatterning. The preparation employed a photo-oxidation-induced crosslinking mechanism. First, furfuryl groups were incorporated into the gelatin. Second, the modified gelatin was mixed in water with Rose Bengal, which is a visible light sensitizer. Irradiation by visible light solidified the aqueous solution. In addition, when the solution was cast on a plate, dried and photo-irradiated in the presence of a photomask a micropattern was formed that matched the micropattern on the photomask. The gelatin-immobilized regions enhanced cell adhesion. It was also confirmed that the gelatin incorporating furfuryl and Rose Bengal have no significant toxicity. The photo-crosslinkable gelatin was employed as a direct pulp capping material in the dental field. Considering these results, this system could be useful as a new type of visible light-induced crosslinkable biosealant.
Keywords :
gelatin , Biosealant , Direct pulp capping , Visible light , Photo-crosslinking
