Title of article :
Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO2 coatings on titanium
Author/Authors :
Hu، نويسنده , , H. and Zhang، نويسنده , , W. and Qiao، نويسنده , , Y. and Jiang، نويسنده , , X. and Liu، نويسنده , , X. and Ding، نويسنده , , C.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
12
From page :
904
To page :
915
Abstract :
In this work, zinc was incorporated into TiO2 coatings on titanium by plasma electrolytic oxidation to obtain the implant with good bacterial inhibition ability and bone-formability. The porous and nanostructured Zn-incorporated TiO2 coatings are built up from pores smaller than 5 μm and grains 20–100 nm in size, in which the element Zn exists as ZnO. The results obtained from the antibacterial studies suggest that the Zn-incorporated TiO2 coatings can greatly inhibit the growth of both Staphylococcus aureus and Escherichia coli, and the ability to inhibit bacteria can be improved by increasing the Zn content in the coatings. Moreover, the in vitro cytocompatibility evaluation demonstrates that the adhesion, proliferation and differentiation of rat bone marrow stem cells (bMSC) on Zn-incorporated coatings are significantly enhanced compared with Zn-free coating and commercially pure Ti plate, and no cytotoxicity appeared on any of the Zn-incorporated TiO2 coatings. Moreover, bMSC express higher level of alkaline phosphatase activity on Zn-incorporated TiO2 coatings and are induced to differentiate into osteoblast cells. The better antibacterial activity, cytocompatibility and the capability to promote bMSC osteogenic differentiation of Zn-incorporated TiO2 coatings may be attributed to the fact that Zn ions can be slowly and constantly released from the coatings. In conclusion, innovative Zn-incorporated TiO2 coatings on titanium with excellent antibacterial activity and biocompatibility are promising candidates for orthopedic and dental implants.
Keywords :
Differentiation , Zn , Antibacterial , Bone Marrow Stem Cells , TIO2
Journal title :
Acta Biomaterialia
Serial Year :
2012
Journal title :
Acta Biomaterialia
Record number :
1755617
Link To Document :
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