Title of article :
In vivo biostability of polyurethane–organosilicate nanocomposites
Author/Authors :
Styan، نويسنده , , Katie E. and Martin، نويسنده , , Darren J. and Simmons، نويسنده , , Anne and Poole-Warren، نويسنده , , Laura A.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
11
From page :
2243
To page :
2253
Abstract :
Organically modified layered silicates were incorporated into a polyether soft-segment polyurethane to form composites of at least delaminated morphology. The primary organic modifier was a quaternary ammonium compound; however, one composite included an alternative amino undecanoic acid-modified silicate. The composites’ biostability was assessed in an in vivo ovine model over a period of 6 weeks. Attenuated total reflectance–Fourier transform infrared analysis and semi-quantitative scanning electron microscopy image rating indicate a significant enhancement of the base polyurethane biostability with the inclusion of silicate at 3 wt.%. The potential effect at 15 wt.% was confounded by probable leaching of the quaternary ammonium compound affecting the tissue response. The amino undecanoic acid composite compared favourably with the quaternary ammonium compound composite of equivalent silicate loading, and offers the promise of a more favourable tissue response.
Keywords :
Nanocomposite , silicate , Organosilicate , biostability , Polyurethane
Journal title :
Acta Biomaterialia
Serial Year :
2012
Journal title :
Acta Biomaterialia
Record number :
1756177
Link To Document :
بازگشت