THE PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITIES OF A MEDICINAL PLANT PHYLLANTHUS INDOFISCHERI BENNET

In India, the plants play a major role as the richest source of many natural products, and the tribal and rural people use these plant products for several ailments. The Phyllanthus species are known for their anti-inflammatory, anti pyretic properties and are also used to treat scurvy, cancer and other heart diseases. Our present work focus on the phytochemical analysis and antimicrobial activities of the Phyllanthus indofischeri using different solvent extracts and doses (25mg/ml and 50mg/ml). The activity of leaf and bark was tried against some common pathogenic bacteria and fungi which include both gram positive and gram negative. The extracts were active against both bacteria and fungi. The highest zone of inhibition was observed with leaf methanol extract (21.33±0.57mm) at 50mg/ml against Escherichia coli. The extract was more active against gram negative bacteria when compared to gram positive and fungi. The inhibitory effect of the extract was compared with standard antibiotics, Ampicillin and Fluconazole. In the present study Phyllanthus indofischeri is extracted with both polar and non-polar solvents. The polar extracts like water and methanol yielded high number of bioactive constituents like tannins, flavonoids, phenols, glycosides, carotenoids, catechols, polyuronoids etc. The methanol and water extracts showed effective inhibition against the bacterial and fungal studied. Therefore, Phyllanthus indofischeri, can be considered as a promising source of antimicrobial compounds.