Author/Authors :
Nickenig، نويسنده , , Georg and Estevez-Loureiro، نويسنده , , Rodrigo and Franzen، نويسنده , , Olaf and Tamburino، نويسنده , , Corrado and Vanderheyden، نويسنده , , Marc and Lüscher، نويسنده , , Thomas F. and Moat، نويسنده , , Neil and Price، نويسنده , , Susanna and Dall’Ara، نويسنده , , Gianni and Winter، نويسنده , , Reidar and Corti، نويسنده , , Roberto and Grasso، نويسنده , , Carmelo and Snow، نويسنده , , Thomas M. and Jeger، نويسنده , , Raban and Blankenberg، نويسنده , , Stefan and Settergren، نويسنده , , Magnus and Tiroch، نويسنده , , Klaus and Balzer، نويسنده , , Jan and Petronio، نويسنده , , Anna Sonia and Büttner، نويسنده , , Heinz-Joachim and Ettori، نويسنده , , Federica and Sievert، نويسنده , , Horst and Fiorino، نويسنده , , Maria Giovanna and Claeys، نويسنده , , Marc and Ussia، نويسنده , , Gian Paolo and Baumgartner، نويسنده , , Helmut and Scandura، نويسنده , , Salvatore and Alamgir، نويسنده , , Farqad and Keshavarzi، نويسنده , , Freidoon and Colombo، نويسنده , , Antonio and Maisano، نويسنده , , Francesco and Ebelt، نويسنده , , Henning and Aruta، نويسنده , , Patrizia and Lubos، نويسنده , , Edith and Plicht، نويسنده , , Bj?rn and Schueler، نويسنده , , Robert and Pighi، نويسنده , , Michele and Di Mario، نويسنده , , Carlo، نويسنده ,
Abstract :
AbstractBackground
e of transcatheter mitral valve repair (TMVR) has gained widespread acceptance in Europe, but data on immediate success, safety, and long-term echocardiographic follow-up in real-world patients are still limited.
ives
m of this multinational registry is to present a real-world overview of TMVR use in Europe.
s
anscatheter Valve Treatment Sentinel Pilot Registry is a prospective, independent, consecutive collection of individual patient data.
s
l of 628 patients (mean age 74.2 ± 9.7 years, 63.1% men) underwent TMVR between January 2011 and December 2012 in 25 centers in 8 European countries. The prevalent pathogenesis was functional mitral regurgitation (FMR) (n = 452 [72.0%]). The majority of patients (85.5%) were highly symptomatic (New York Heart Association functional class III or higher), with a high logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation) (20.4 ± 16.7%). Acute procedural success was high (95.4%) and similar in FMR and degenerative mitral regurgitation (p = 0.662). One clip was implanted in 61.4% of patients. In-hospital mortality was low (2.9%), without significant differences between groups. The estimated 1-year mortality was 15.3%, which was similar for FMR and degenerative mitral regurgitation. The estimated 1-year rate of rehospitalization because of heart failure was 22.8%, significantly higher in the FMR group (25.8% vs. 12.0%, p[log-rank] = 0.009). Paired echocardiographic data from the 1-year follow-up, available for 368 consecutive patients in 15 centers, showed a persistent reduction in the degree of mitral regurgitation at 1 year (6.0% of patients with severe mitral regurgitation).
sions
ndependent, contemporary registry shows that TMVR is associated with high immediate success, low complication rates, and sustained 1-year reduction of the severity of mitral regurgitation and improvement of clinical symptoms.
