Title of article :
Altered expression and localization of desmoglein 3 in esophageal squamous cell carcinoma
Author/Authors :
Fang، نويسنده , , Wang-Kai and Chen، نويسنده , , Bo and Xu، نويسنده , , Xiu-E and Liao، نويسنده , , Lian-Di and Wu، نويسنده , , Zhiyong and Wu، نويسنده , , Jian-Yi and Shen، نويسنده , , Jian and Xu، نويسنده , , Liyan and Li، نويسنده , , En-Min، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
7
From page :
803
To page :
809
Abstract :
Desmoglein 3 (DSG3), a transmembrane cadherin of the desmosomal cell–cell adhesion structure, plays vital roles in the maintenance of normal epithelial tissue architecture. Reports implicating a role for DSG3 expression in cancer are few and contradictory. In this study, immunohistochemical staining was employed to investigate DSG3 expression and subcellular localization in esophageal squamous cell carcinoma (ESCC), and to correlate changes with clinical characteristics. Results indicate that in normal squamous cell epithelia, strong DSG3 immunoreactivity was observed in the Stratum spinosum, and localization occurred only at the cell membrane. In ESCC, DSG3 immunoreactivity displayed an abnormal cytoplasmic localization that was correlated with cell differentiation (P = 0.018). Most strikingly, in 74.1% of the tumors, DSG3 expression was up-regulated and correlated with regional lymph node metastasis (P = 0.036). Moreover, in patients without lymph node metastasis, cytoplasmic localization of DSG3 correlated with poor prognosis (P = 0.044). These results suggest that DSG3 is involved in the development of ESCC and imply that DSG3 overexpression is likely to be an essential contributor to the aggressive features of esophageal cancer.
Keywords :
Desmoglein 3 , Esophageal squamous cell carcinoma , Prognosis
Journal title :
Acta Histochemica
Serial Year :
2014
Journal title :
Acta Histochemica
Record number :
1760361
Link To Document :
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