Changes of intrathecal immunoglobulin synthesis in various types of dementias

Our examinations were finished on 80 patients with different dementia forms. We specified the concentration of liquor immunoglobulins with the nephelometrical method, and concluded the presence of intrathecal immunoglobulin (IgG, IgM and IgA) synthesis on the basis of the Link index. In the cases of senile dementia, SDAT and AD, we found altered blood-brain barrier function. We detected intrathecal IgG and IgA synthesis at AD patients, while the synthesis of all the three immunoglobulins was characteristic for the Jakob-Creutzfeld disease. On the basis of our results, we came to the conclusion that, at the different dementias, the immunopathological occurrences play different roles in the development of the disease.