Sex difference in gene expressions of cholecystokinin (CCK) and CCK receptor in young and old rats

The gene expressions of cholecystokinin (CCK) in the proximal small intestinal mucosa and CCK-A receptor in the pancreas were examined in male and female young (4–8 months old) and old (26–29 months old) rats. Their concentrations of CCK in the intestine were also compared. In males, but not in females, the mRNA levels of CCK in the intestine and those of the CCK-A receptor in the pancreas were significantly lower in old than young rats. In females, but not in males, the tissue content of CCK in the proximal intestinal mucosa was significantly higher in old rats. The pancreatic wet weight and trypsin activity in the proximal lumen were similar in young and old rats of both sexes. Therefore, changes in the regulations of gene expressions of CCK and the CCK receptor with age differ in male and female rats.