Title of article :
Mitochondrial DNA metabolism targeting drugs
Author/Authors :
Rowe، نويسنده , , Thomas C and Weissig، نويسنده , , Volkmar and Lawrence، نويسنده , , Jeffrey W، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase γ and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented.
Keywords :
Mitochondria , REPLICATION , topoisomerase , Viral , Lipophilic , polymerase , intercalator , Dideoxynucleoside , polyamine , Inhibitor
Journal title :
Advanced Drug Delivery Reviews
Journal title :
Advanced Drug Delivery Reviews
