Author/Authors :
Suh ، نويسنده , , Yoo-Hun and Choi، نويسنده , , Woong and Kim، نويسنده , , Seong-Hun and Kim، نويسنده , , Jong-Suk and Rhi، نويسنده , , Bou-Yong and Chong، نويسنده , , Young Hae and Woo، نويسنده , , Jong Inn and Lee، نويسنده , , Kwang-Woo، نويسنده ,
Abstract :
β-Amyloid precursor protein (βAPP) has been shown to be involved in cell growth regulation. In spleen, the majority of cells showing βAPP like immunoreactivity was found in the T cell-dependent zone. In Northern blot, the expression of βAPP was increased to reach the peak at 72 h after the treatment of phytohemagglutinin (PHA). But, in cytofluorometry, almost all CD4+ T helper/inducer cells and the majority of CD8+ T suppressor/cytotoxic cells show βAPP immunoreactivity which remained constant during the stimulation with PHA. These results suggest that βAPP is a surface molecule of T lymphocyte and the turnover or release of APP might be increased with the treatment of T cell mitogen.
