Title of article :
Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences
Author/Authors :
Okamura، نويسنده , , Hitoshi and Doi، نويسنده , , Masao and Fustin، نويسنده , , Jean-Michel and Yamaguchi، نويسنده , , Yoshiaki and Matsuo، نويسنده , , Masahiro، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
9
From page :
876
To page :
884
Abstract :
An internal circadian (from the Latin “circa” meaning “about” and “dien” meaning “day”) clock has been found across kingdoms of life, a testimony that circadian rhythms are a basic feature of life on earth. Physiologically relevant circadian time is generated at the level of transcription–(post)translation feedback loop of clock genes, which machinery can be found in most cells throughout the body. Lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolish clock oscillations in the body, indicating thereby that rhythm generation is a hierarchial system with the SCN at the top. Disrupting this exquisitely harmonious system causes abnormal expression of cell-type specific clock-controlled genes, as revealed by the etiology of life-style related diseases such as hypertension.
Keywords :
Clock-controlled genes , suprachiasmatic nucleus , Transcription–translation feedback loop , Circadian rhythm , Clock genes , Peripheral clock , hypertension
Journal title :
Advanced Drug Delivery Reviews
Serial Year :
2010
Journal title :
Advanced Drug Delivery Reviews
Record number :
1762920
Link To Document :
بازگشت