Title of article :
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
Author/Authors :
Acharya، نويسنده , , Sarbari and Sahoo، نويسنده , , Sanjeeb K.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
Summary
tality due to cancer continues to rise, advances in nanotechnology have significantly become an effective approach for achieving efficient drug targeting to tumour tissues by circumventing all the shortcomings of conventional chemotherapy. During the past decade, the importance of polymeric drug-delivery systems in oncology has grown exponentially. In this context, poly(lactic-co-glycolic acid) (PLGA) is a widely used polymer for fabricating ‘nanoparticles’ because of biocompatibility, long-standing track record in biomedical applications and well-documented utility for sustained drug release, and hence has been the centre of focus for developing drug-loaded nanoparticles for cancer therapy. Such PLGA nanoparticles have also been used to develop proteins and peptides for nanomedicine, and nanovaccines, as well as a nanoparticle-based drug- and gene-delivery system for cancer therapy, and nanoantigens and growth factors. These drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect. Ongoing research about drug-loaded nanoparticles and their delivery by the EPR effect to the tumour tissues has been elucidated in this review with clarity.
Keywords :
Drug-loaded nanoparticles , chemotherapy , NANOTECHNOLOGY , EPR Effects , DRUG DELIVERY
Journal title :
Advanced Drug Delivery Reviews
Journal title :
Advanced Drug Delivery Reviews