Title of article
Promise and problems in relating cellular senescence in vitro to aging in vivo
Author/Authors
Rubin، نويسنده , , Harry، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
12
From page
275
To page
286
Abstract
According to the ‘Hayflick limit’, human fetal fibroblasts have a uniform, limited replicative lifespan of about 50 population doublings in cell culture. This concept was extrapolated to diverse cells in the body. It seemed to decrease with the age of the
Keywords
Telomerases , Fibroblasts in vitro , Hayflickיs limit , In vitro aging , Lipofuscin production in vitro , telomeres , In vivo aging
Journal title
Archives of Gerontology and Geriatrics
Serial Year
2002
Journal title
Archives of Gerontology and Geriatrics
Record number
1764863
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