Author/Authors :
Perrotta، نويسنده , , Carla and Kleefeld، نويسنده , , Silke and Staines، نويسنده , , Anthony and Tewari، نويسنده , , Prerna and De Roos، نويسنده , , Anneclaire J. and Baris، نويسنده , , Dalsu and Birmann، نويسنده , , Brenda K.W Chiu، نويسنده , , Brian and Cozen، نويسنده , , Wendy and Becker، نويسنده , , Nikolaus and Foretova، نويسنده , , Lenka and Maynadié، نويسنده , , Marc and Nieters، نويسنده , , Alexandra and de Sanjosé، نويسنده , , Silvia and Miligi، نويسنده , , Lucia and Seniori Costantini، نويسنده , , Adele and Purdue، نويسنده , , Mark and Spinelli، نويسنده , , John and Cocco، نويسنده , , Pierluigi، نويسنده ,
Abstract :
Objective: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case–control studies. Methods: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). Results: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR = 1.50, 95% CI 0.9–2.3), while other farming jobs did not. Metal processors (OR = 1.55, 95% CI 0.9–2.3), female cleaners (OR = 1.32, 95% CI 1.0–1.8), and high level exposure to organic solvents (OR = 1.38, 95% CI 0.96–1.8) also showed moderately increased risks. Conclusions: Additional case–control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
Keywords :
Multiple myeloma , Case–control study , Solvents , Agriculture , farmers
