Author/Authors :
Merritt، نويسنده , , Melissa A. and Riboli، نويسنده , , Elio and Weiderpass، نويسنده , , Elisabete and Tsilidis، نويسنده , , Konstantinos K. and Overvad، نويسنده , , Kim and Tjّnneland، نويسنده , , Anne and Hansen، نويسنده , , Louise and Dossus، نويسنده , , Laure and Fagherazzi، نويسنده , , Guy and Baglietto، نويسنده , , Laura and Fortner، نويسنده , , Renée T. and Ose، نويسنده , , Jennifer and Steffen، نويسنده , , Annika and Boeing، نويسنده , , Heiner and Trichopoulou، نويسنده , , Antonia and Trichopoulos، نويسنده , , Dimitrios and Lagiou، نويسنده , , Pagona and Masala، نويسنده , , Giovanna and Sieri، نويسنده , , Sabina and Mattiello، نويسنده , , Amalia and Tumino، نويسنده , , Rosario and Sacerdote، نويسنده , , Carlotta and Bueno-de-Mesquita، نويسنده , , H. B(as) and Onland-Moret، نويسنده , , N. Charlotte and Peeters، نويسنده , , Petra H. and Hjartهker، نويسنده , , Anette and Gram، نويسنده , , Inger Torhild and Quirَs، نويسنده , , J. Ramَn and Obَn-Santacana، نويسنده , , Mireia and Molina-Montes، نويسنده , , Esther and Huerta Castaٌo، نويسنده , , José Marيa and Ardanaz، نويسنده , , Eva and Chamosa، نويسنده , , Saioa and Sonestedt، نويسنده , , Emily and Idahl، نويسنده , , Annika and Lundin، نويسنده , , Eva and Khaw، نويسنده , , Kay-Tee and Wareham، نويسنده , , Nicholas and Travis، نويسنده , , Ruth C. and Rinaldi، نويسنده , , Sabina and Romieu، نويسنده , , Isabelle and Chajes، نويسنده , , Veronique and Gunter، نويسنده , , Marc J.، نويسنده ,
Abstract :
There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n = 1095) and borderline (n = 96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR = 1.22, 95% CI = 1.02–1.48, Ptrend = 0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.
