Title of article :
Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8
Author/Authors :
Tomobe، نويسنده , , Koji and Shinozuka، نويسنده , , Tatsuo and Kawashima، نويسنده , , Tsuyoshi and Kawashima-Ohya، نويسنده , , Yoshie and Nomura، نويسنده , , Yasuyuki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
SAMP8 exhibits accelerated aging and a short lifespan. Insulin-like growth factor-1 receptor (IGF-1R)/FOXO pathway is associated with aging. Phosphorylation of IGF-1R, Akt, and FOXO1 was found to be increased during aging in the liver of SAMR1 normal agin
Keywords :
longevity , Foxo1 , IGF-1R , SAMP8 , Antioxidant enzyme , senescence
Journal title :
Archives of Gerontology and Geriatrics
Journal title :
Archives of Gerontology and Geriatrics
