Author/Authors :
Haas، نويسنده , , H. and Caetano، نويسنده , , W. and Borissevitch، نويسنده , , G.P. and Tabak، نويسنده , , M. and Mosquera Sanchez، نويسنده , , M.I. and Oliveira Jr.، نويسنده , , O.N. and Scalas، نويسنده , , Enrico and Goldmann، نويسنده , , Michel، نويسنده ,
Abstract :
Incorporation of dipyridamole (DIP) in Langmuir monolayers of the zwitterionic phospholipid dipalmitoylphosphatidylcholine (DPPC) has been investigated using surface pressure isotherm and grazing incidence X-ray diffraction (GIXD) measurements. An expansion in the pressure–area isotherms of the DPPC monolayer was observed, which was maximum in the liquid-expanded (LE) to liquid-condensed (LC) transition region and at a DIP concentration of 2 mol%. Accordingly, the GIXD measurements indicated an expansion of the 2D lattice in the LC phase up to a surface pressure of ca. 30 mN/m. A condensation effect on the DPPC packing for high DIP concentrations, as previously suggested, can be ruled out.
