Title of article
Nuclear relaxation studies in ligand-macromolecule affinity index determinations
Author/Authors
Rossi، نويسنده , , Claudio and Donati، نويسنده , , Alessandro and Bonechi، نويسنده , , Claudia and Corbini، نويسنده , , Gianfranco and Rappuoli، نويسنده , , Roberto and Dreassi، نويسنده , , Elena and Corti، نويسنده , , Piero، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
5
From page
205
To page
209
Abstract
An ‘affinity index’, representing the global affinity between a ligand and a biomacromolecular receptor, is proposed. It is determined as the slope of the linear relations between ΔR1SE and the receptor concentration and has the advantage of providing a measure of the ligand-biomacromolecule global affinity which is independent of the number of interaction sites. The method was applied to the calculation of the lamotrigine-albumin affinity index.
Journal title
Chemical Physics Letters
Serial Year
1997
Journal title
Chemical Physics Letters
Record number
1779249
Link To Document