Title of article
DFT study of the reaction proceeding in the cytidine deaminase
Author/Authors
Kedzierski، نويسنده , , Pawel and Sokalski، نويسنده , , W.Andrzej and Cheng، نويسنده , , Hansong and Mitchell، نويسنده , , John and Leszczynski، نويسنده , , Jerzy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
660
To page
665
Abstract
The deamination of cytidine performed by cytidine deaminase has been modeled using density functional theory yielding a reaction mechanism differing from that previously reported using semiempirical results. The main difference consists in the initial reaction step starting with Zn-bound water and N3-protonated cytidine. This study allows for the first time to close complete reaction cycle for the investigated process.
Journal title
Chemical Physics Letters
Serial Year
2003
Journal title
Chemical Physics Letters
Record number
1784343
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