Author/Authors :
Kedzierski، نويسنده , , Pawel and Sokalski، نويسنده , , W.Andrzej and Cheng، نويسنده , , Hansong and Mitchell، نويسنده , , John and Leszczynski، نويسنده , , Jerzy، نويسنده ,
Abstract :
The deamination of cytidine performed by cytidine deaminase has been modeled using density functional theory yielding a reaction mechanism differing from that previously reported using semiempirical results. The main difference consists in the initial reaction step starting with Zn-bound water and N3-protonated cytidine. This study allows for the first time to close complete reaction cycle for the investigated process.
