Structure and transformation of the niosome prepared from PEG 6000/Tween 80/Span 80/H2O lamellar liquid crystal

The microstructure and transformation of the niosome prepared from poly(ethylene glycol) (PEG) 6000/Tween 80/Span 80/H2O lamellar liquid crystal (LLC) are studied by the methods of freeze fracture-TEM, negative-staining TEM, dynamic light scattering technique and micropolarity measurements. The size of the niosome made from the LLC is little larger than that from directly mixing samples. The layer membrane of the former niosome is looser than that of the later niosome. The former niosome is held with the partial behaviors of the LLC and can tend to be transformed into the later niosome.