Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain

Background m of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin. s rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 μM/kg (440 μg) of BHT. s of TBARS and 5-HTP increased considerably (p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially (p <0.05) only in B6 with or without BHT-treated groups compared with control group. sions s suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP.