Author/Authors :
Sogawa، نويسنده , , Kenichi and Yamada، نويسنده , , Takahisa and Oka، نويسنده , , Shiro and Kawasaki، نويسنده , , Kojiro and Mori، نويسنده , , Satoshi and Tanaka، نويسنده , , Hideki and Norimatsu، نويسنده , , Hiromichi and Cai، نويسنده , , Yiqiang and Kuwabara، نويسنده , , Hiroko and Shima، نويسنده , , Hiroshi and Nagao، نويسنده , , Minako and Matsumoto، نويسنده , , Kozo، نويسنده ,
Abstract :
The expressions of the three catalytic subunits of protein phosphatase (PP) type 1 and 2A, PP1α, PP1γ1, and PP2AC, were examined in 14 cases of three types of osteogenic tumor using immunohistochemical analysis. The percentage of tumor cells stained positively with antiserum against PP1 catalytic subunit isoform PP1γ1 was significantly higher in malignant osteogenic tumors than in benign osteogenic tumors. Furthermore, malignant osteogenic tumor showed markedly high S-phase fraction in the cell cycle of tumor cells, as compared to benign osteogenic tumors. These results suggest that PP1γ1 is involved in the accelerated growth of malignant cells in osteogenic tumors.
Keywords :
protein phosphatase type 1 , Malignancy , GROWTH , Osteogenic tumor
