Title of article :
Myelin-Basic Protein-reactive Specific CD4+ and CD8+ NK Lymphocytes Induce Morphological Changes in Neuronal Cell Bodies and Myelin Sheaths: Implications for Multiple Sclerosis
Author/Authors :
Quan-yu، نويسنده , , Zhang and Jing-hui، نويسنده , , Huang and Hong-zeng، نويسنده , , Li and Hai-tao، نويسنده , , Guo and Yanqing، نويسنده , , Zhong and Yue-min، نويسنده , , Wang and Jian-ming، نويسنده , , Pei، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
7
From page :
45
To page :
51
Abstract :
Background le sclerosis (MS) is a chronic disease characterized by loss of myelin. However, data indicate that autoimmune cells could directly impair neuronal cell bodies and myelin sheath is lacking. The aim of the present study was to determine morphological evidence of the direct impairment of neurons by autoreactive lymphocytes and to further identify the subtypes of these lymphocytes. s cytes activated by myelin basic protein (MBP) 83–99 and neurons of human brain were co-cultured for 24 h. s ations through scanning electron microscope showed that MBP-specific lymphocytes (CD4+, CD8+ cells, and NK cells) aggregated in the vicinity of the neuronal cell bodies and the myelin sheaths and attacked them directly, resulting in the degeneration of both neurons. sions udies provide morphological evidences of the direct impairment of neuronal cell bodies and myelin sheaths by MBP-specific lymphocytes. Our studies also suggest that MBP-specific CD4+, CD8+, and NK cells might be involved in this process. These processes may play a role in the direct impairment of neurons and myelin sheaths in early stages of MS and provide evidences for the application of immunosuppressant therapy of MS.
Keywords :
lymphocyte , Multiple sclerosis , Autoimmune process , Myelin basic protein , Neuron
Journal title :
Archives of Medical Research
Serial Year :
2008
Journal title :
Archives of Medical Research
Record number :
1796434
Link To Document :
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