Author/Authors :
Tamai، نويسنده , , Mikiko and Tanimura، نويسنده , , Hiroshi and Yamaue، نويسنده , , Hiroki and Iwahashi، نويسنده , , Makoto and Tsunoda، نويسنده , , Takuya and Tani، نويسنده , , Masaji and Noguchi، نويسنده , , Kohei and Mizobata، نويسنده , , Shizuma and Hotta، نويسنده , , Tsukasa and Arii، نويسنده , , Kazuo and Terasawa، نويسنده , , Hiroshi، نويسنده ,
Abstract :
The expression of carcinoembryonic antigen(CEA) on tumor cells freshly excised from 51 patients with gastric cancer was studied using flow cytometry. The expression of CEA by flow cytometry was more quantitative than that by immunohistochemical staining. There was no relationship between the fluorescence intensity assessed by flow cytometry and serum CEA levels, except for patients with a high titer of serum CEA. The patients with high grade CEA expression on tumor cells by flow cytometry had poor prognoses, compared to patients with low CEA expression in undifferentiated gastric cancer. Thus, it is suggested that the quantitative CEA expression on tumor cells by flow cytometry could be a useful prognostic marker in postoperative gastric cancer patients.
Keywords :
Carcinoembryonic antigen , Gastric cancer , flow cytometry , Prognosis of gastric cancer patients , Immunohistochemical staining
