Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin

Rapid cell death, as evidenced by a decrease in cell counts, was observed when molt-4-lymphoblastoid cells, a human leukemia cell line, were exposed to holotransferrin (12 μM) and dihydroartemisinin (1–200 μM). Incubation with either compound alone was significantly less effective. Significantly less cell death was observed when normal human lymphocytes were exposed to a combination of these 2 drugs. Probit analysis of dose-response functions shows that the drug combination is approximately 100 times more effective on molt-4 cells than lymphocytes (LD50s for molt-4 and lymphocytes were 2.59 μM and 230 μM, respectively). This drug combination may provide a novel approach for cancer treatment.