Title of article :
The effects of end point overdispersions on the validity of single-dose tumorigenicity assays
Author/Authors :
Lewis Jr.، نويسنده , , Andrew M. and Banks، نويسنده , , Steven M. and Soddu، نويسنده , , Silvia and Cook، نويسنده , , James L.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
8
From page :
179
To page :
186
Abstract :
Overdispersion can be found in tumor incidence and tumor latency end point values obtained by the conventional assays that are being used to assess the tumorigenicity of neoplastic cells growing in tissue culture. Failure to account for such wide variations in end point data can lead to incorrect assessments of the neoplastic cell tumorigenic phenotype and misinterpretations of data relating genetic functions to tumor-forming capacity. This problem suggests the need for more detailed analyses of the relationships that exist between tumor cell dose and the parameters being used to measure tumorigenicity.
Keywords :
Tumorigenicity assay , DNA tumor virus , Animal model
Journal title :
Cancer Letters
Serial Year :
1995
Journal title :
Cancer Letters
Record number :
1796835
Link To Document :
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