Author/Authors :
Kornmann، نويسنده , , Marko and Link، نويسنده , , Karl H. and Lenz، نويسنده , , Heinz-Josef and Pillasch، نويسنده , , Jürgen O. Metzger، نويسنده , , Ralf and Butzer، نويسنده , , Urwe and Leder، نويسنده , , Gerhard H. and Weindel، نويسنده , , Marlen and Safi، نويسنده , , Farouk and Danenberg، نويسنده , , Kathleen D. and Beger، نويسنده , , Hans G. and Danenberg، نويسنده , , Peter V.، نويسنده ,
Abstract :
The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 × 10−3 (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.
Keywords :
chemotherapy , Colorectal Cancer , Hepatic artery infusion , thymidylate synthase , Predictive parameter , Chemosensitivity
