Title of article
Mammalian artificial chromosomes — vectors for somatic gene therapy
Author/Authors
Ascenzioni، نويسنده , , F. M. Donini، نويسنده , , P. E. Lipps، نويسنده , , H.J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
8
From page
135
To page
142
Abstract
Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.
Keywords
replication origins , telomeres , Centromeres , Chromosome assembly
Journal title
Cancer Letters
Serial Year
1997
Journal title
Cancer Letters
Record number
1798729
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