Title of article
Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C
Author/Authors
Hoelting، نويسنده , , Thomas and Duh، نويسنده , , Quan-Yang and Clark، نويسنده , , Orlo H. and Herfarth، نويسنده , , Christian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
5
From page
1
To page
5
Abstract
Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133. Antagonism of PKC reversed TSH-mediated stimulation, whereas it had no effect on EGF-stimulation. Our data provide evidence for an essential role of PKC in signal transduction of invasive thyroid cancer.
Keywords
Thyroid cancer , Protein kinase C , Signal transduction
Journal title
Cancer Letters
Serial Year
1997
Journal title
Cancer Letters
Record number
1798763
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