Author/Authors :
Yatsunami، نويسنده , , Jun and Tsuruta، نويسنده , , Nobuko and Ogata، نويسنده , , Kenichi and Wakamatsu، نويسنده , , Kentaro and Takayama، نويسنده , , Koichi and Kawasaki، نويسنده , , Masayuki and Nakanishi، نويسنده , , Yoichi and Hara، نويسنده , , Nobuyuki and Hayashi، نويسنده , , Shin-ichiro، نويسنده ,
Abstract :
We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8ʹs contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.
Keywords :
interleukin-8 , immunohistochemistry , Angiogenesis , lung cancer
