Author/Authors :
Umemura، نويسنده , , Shin-ichiro and Yumita، نويسنده , , Nagahiko and Okano، نويسنده , , Yukihiro and Kaneuchi، نويسنده , , Masahiro and Magario، نويسنده , , Naoki and Ishizaki، نويسنده , , Midori and Shimizu، نويسنده , , Keiko and Sano، نويسنده , , Yasuko and Umemura، نويسنده , , Koshiro and Nishigaki، نويسنده , , Ryuichiro، نويسنده ,
Abstract :
Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40–160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.
Keywords :
Ultrasound , adriamycin , Sonochemistry , Cell damage , Active oxygen
