Title of article
T-cell receptor-γ rearrangement and c-myb methylation in MNNG-exposed Bloom syndrome B-lymphoblastoid cells
Author/Authors
Bhalla، نويسنده , , Alka and Sachdeva، نويسنده , , Geetanjali and Bamezai، نويسنده , , R، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1
To page
6
Abstract
The MNNG-exposed Bloom syndrome (BS) B-lymphoblastoid cell population (BS-MNNG), when analyzed for aberrant genetic variations, showed an illegitimate rearrangement at the TCR-γ gene and hypermethylation at the c-myb protooncogene. The TCR-γ rearrangement involved a Vγ9 segment corresponding to a 4 kb band detected with a Jγ-specific probe in HindIII-digested DNA samples from BS-MNNG cells only. These variations were not shown by unexposed BS cells or both MNNG-exposed and unexposed normal (GA3) B-lymphoblastoid cells.
Keywords
T-cell receptor-? rearrangement , c-myb methylation , MNNG-exposed Bloom syndrome B-lymphoblastoid cells
Journal title
Cancer Letters
Serial Year
1998
Journal title
Cancer Letters
Record number
1799434
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