Author/Authors :
Llovera، نويسنده , , Marta and Carb?، نويسنده , , Neus and Lopez-Soriano، نويسنده , , Joaqu??n and Garc??a-Mart??nez، نويسنده , , Cèlia and Busquets، نويسنده , , S??lvia and Alvarez، نويسنده , , Belén and Agell، نويسنده , , Neus and Costelli، نويسنده , , Paola and L?pez-Soriano، نويسنده , , Francisco J. and Celada، نويسنده , , Antonio and Argilés، نويسنده , , Josep M.، نويسنده ,
Abstract :
Intravenous administration of different cytokines caused important changes in the expression of ubiquitin genes in skeletal muscle. Tumour necrosis factor-α caused a 2.2- and 1.9-fold increase in the expression of the 2.4 and 1.2 kb transcripts, respectively. Administration of interferon-γ also caused a 2.2- and 1.8-fold increase in the 2.4 and 1.2 kb transcripts, respectively. While administration of leukaemia inhibitory factor and interleukin-6 resulted in no changes in ubiquitin gene expression, interleukin-1 administration also caused an increase in both ubiquitin gene transcripts (2.8- and 1.9-fold for the 2.4 and 1.2 kb transcripts, respectively). The results suggest that some of the cytokine effects on the ubiquitin system gene expression could be related to the enhanced skeletal muscle proteolysis found during cancer cachexia and other pathological states.
Keywords :
cancer cachexia , Muscle waste , IL-1 , TNF-? , IL-6 , IFN-? , LIF
