Title of article :
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines
Author/Authors :
Kamataki، نويسنده , , Tetsuya and Suzuki، نويسنده , , Akihiro and Kushida، نويسنده , , Hirotaka and Iwata، نويسنده , , Hiroshi C. Watanabe، نويسنده , , Masahiko and Nohmi، نويسنده , , Takehiko and Fujita، نويسنده , , Ken-ichi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
4
From page :
113
To page :
116
Abstract :
A co-expression plasmid (p1A2OR) carrying human CYP1A2 and NADPH-P450 reductase cDNAs and an expression plasmid (pOAT) carrying Salmonella TA1538/ARO cells. The CYP and OAT expressed in the Salmonella cells showed catalytic activity. The TA1538/ARO strain exhibited high sensitivity to heterocyclic amines (HCAs) such as 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimenthylimidazo[4,5-f]quinoline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as compared with the parent Ames tester strain TA1538. It is suggested that the intracellular expression of drug-metabolising enzymes makes the Salmonella cells highly sensitive to the HCAs.
Keywords :
Salmonella tester strain , Mutagenic heterocyclic amines
Journal title :
Cancer Letters
Serial Year :
1999
Journal title :
Cancer Letters
Record number :
1800526
Link To Document :
بازگشت