Author/Authors :
Iwase ، نويسنده , , Yukiko and Takemura، نويسنده , , Yuko and Ju-ichi، نويسنده , , Motoharu and Ito، نويسنده , , Chihiro and Furukawa، نويسنده , , Hiroshi and Kawaii، نويسنده , , Satoru and Yano، نويسنده , , Masamichi and Mou، نويسنده , , Xiao Yang and Takayasu، نويسنده , , Junko and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
To search for possible anti-tumor promoters, thirteen flavones (1–13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein–Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3′,4′-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Keywords :
Flavone , citrus , Anti-tumor promoter , Two-stage carcinogenesis
