Author/Authors :
Matsumoto، نويسنده , , Koji and Yoshikawa، نويسنده , , Hiroyuki and Nakagawa، نويسنده , , Shunsuke and Tang، نويسنده , , Xiaohai and Yasugi، نويسنده , , Toshiharu and Kawana، نويسنده , , Kei and Sekiya، نويسنده , , Souei and Hirai، نويسنده , , Yasuo and Kukimoto، نويسنده , , Iwao and Kanda، نويسنده , , Tadahito and Taketani، نويسنده , , Yuji، نويسنده ,
Abstract :
To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype (P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.
