Author/Authors :
Fukutake، نويسنده , , Masato and Miura، نويسنده , , Naoko and Yamamoto، نويسنده , , Masahiro and Fukuda، نويسنده , , Kazunori and Iijima، نويسنده , , Osamu and Ishikawa، نويسنده , , Hiroki and Kubo، نويسنده , , Masayoshi and Okada، نويسنده , , Minoru and Komatsu، نويسنده , , Yasuhiro and Sasaki، نويسنده , , Hiroshi and Wakabayashi، نويسنده , , Keiji and Ishige، نويسنده , , Atsushi and Amagaya، نويسنده , , Sakae، نويسنده ,
Abstract :
The present study is part of a program to obtain effective chemopreventive agents with low toxicity from medicinal herbs and traditional herbal medicines. We previously reported that Oren (Coptidis rhizoma) and Ogon (Scutellariae radix) inhibit azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation. In the present investigation, we found Sanshishi (Gardeniae fructus) and the traditional herbal medicine Oren-gedoku-to (OGT), composed of Ogon, Oren, Sanshishi and Obaku, also have preventive potential. Sanshishi and OGT decreased the numbers of ACF to 25.2 and 59.4% of the control value at 2% in the diet, respectively. Adverse effects, evidenced by body weight loss, were weaker with OGT than component herbs. To investigate their mechanisms of action, the influence on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) activities was studied. Both OGT and Sanshishi inhibited COX-2 but not COX-1, this presumably contributing to their suppressive effects on ACF development. The results suggest that OGT may be useful for colon cancer chemoprevention in terms of efficacy and toxicity.
Keywords :
Oren-gedoku-to , Cyclooxygenase-2 , Aberrant crypt foci , chemoprevention , Herbal medicine
