Title of article
Detection of mammaglobin expressing cells in blood of breast cancer patients
Author/Authors
Suchy، نويسنده , , Bernhard and Austrup، نويسنده , , Frank and Driesel، نويسنده , , Gerhard and Eder، نويسنده , , Claudine and Kusiak، نويسنده , , Ilona and Uciechowski، نويسنده , , Peter and Grill، نويسنده , , Hans-Jِrg and Giesing، نويسنده , , Michael، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
8
From page
171
To page
178
Abstract
Expression of human mammaglobin (hMAM) was published to be exclusively expressed in mammary tissue, in solid tumors, axillary lymph nodes and disseminated cancer cells in blood of breast cancer patients. A quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) test was applied to investigate hMAM expression in blood of breast cancer patients. Mammaglobin mRNA expression was found not only in breast cancer cell lines but also in cell lines of other cancer origin. In our patient cohort hMAM expression in 11/98 (11%) samples of breast cancer and 3/12 (25%) ovarian cancer patients could be detected. hMAM mRNA expression as a candidate marker for the detection of disseminated cancer cells in blood of breast cancer patients showed low sensitivity and reduced tissue specificity. A prognostic significance of hMAM expression could not be demonstrated.
Keywords
Human mammoglobin , Tumor cell lines , breast cancer , Blood , Disseminated cancer cells , Ovarian cancer
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801761
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