Author/Authors :
Natsugoe، نويسنده , , Shoji and Matsumoto، نويسنده , , Masataka and Nakashima، نويسنده , , Saburo and Okumura، نويسنده , , Hiroshi and Miyazono، نويسنده , , Futoshi and Kijima، نويسنده , , Fumio and Ishigami، نويسنده , , Sumiya and Aridome، نويسنده , , Kuniaki and Kusano، نويسنده , , Chikara and Baba، نويسنده , , Masamichi and Takao، نويسنده , , Sonshin and Aikou، نويسنده , , Takashi، نويسنده ,
Abstract :
Micrometastasis (MM) and tumor cell microinvolvement (TCM) in the lymph node were immunohistochemically evaluated using the cytokeratin (CK) antibody between a surgery group (n=20; 929 lymph nodes) and a chemotherapy group (n=20; 1052 lymph nodes). The incidence of MM±TCM in the surgery and chemotherapy groups was 50.0 (10/20) and 55.0% (11/20), respectively. Limiting the analysis to TCM alone revealed that the incidence in the chemotherapy group (10.0%; 2/20) was significantly lower than that in the surgery group (40.0%; 8/20; P=0.032). Preoperative chemotherapy in this regime was not effective, except for some patients with TCM alone.
Keywords :
Tumor cell microinvolvement , Cytokeratin , Esophageal cancer , Lymph node metastasis , Micrometastasis , chemotherapy
