Author/Authors :
Ishida، نويسنده , , Junko and Kozuka، نويسنده , , Mutsuo and Wang، نويسنده , , Hui-Kang and Konoshima، نويسنده , , Takao and Tokuda، نويسنده , , Harukuni and Okuda، نويسنده , , Masato and Yang Mou، نويسنده , , Xiao and Nishino، نويسنده , , Hoyoku and Sakurai، نويسنده , , Nobuko and Lee، نويسنده , , Kuo-Hsiung and Nagai، نويسنده , , Masahiro، نويسنده ,
Abstract :
Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein–Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors.
Keywords :
Antitumor-promoting effect , Epstein–Barr virus activation test , Two-stage skin carcinogenesis test , Cyclic diaryl heptanoids , Myricanone
