Title of article :
Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr
Author/Authors :
Tanaka، نويسنده , , Reiko and Ohtsu، نويسنده , , Hironori and Iwamoto، نويسنده , , Manabu and Minami، نويسنده , , Toshifumi and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Matsunaga، نويسنده , , Shunyo and Yoshitake، نويسنده , , Akira، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Seven labdane-type diterpenoids from the stem bark of Thuja standishii (Gord.) Carr. (Cupressaceae) and their analogues showed strong inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Among these compounds, 15,16-bisnor-13-oxolabda-8(17),11E-dien-19-oic acid was revealed to have the strongest inhibitory effect on the EBV-EA activation, being stronger than that of β-carotene which has been intensively studied in cancer prevention using animal models. 15,16-bisnor-13-Oxolabda-8(17),11E-dien-19-oic acid was also found to exhibit the excellent anti-tumor promoting activity in two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene and TPA.
Keywords :
Thuja standishii (Gord.) Carr , CUPRESSACEAE , Anti-tumor promoter , 15 , Two stage carcinogenesis , 16-bisnor-13-Oxolabda-8(17) , Epstein–Barr virus , labdane , Diterpenoid , 11E-dien-19-oic acid
Journal title :
Cancer Letters
Journal title :
Cancer Letters
