Title of article
Combined analysis of MIB-1 and thyroid transcription factor-1 predicts survival in non-small cell lung carcinomas
Author/Authors
Puglisi، نويسنده , , Fabio and Aprile، نويسنده , , Giuseppe and Bruckbauer، نويسنده , , Michiela and Barbone، نويسنده , , Fabio and Damante، نويسنده , , Giuseppe and Guerra، نويسنده , , Sabrina and Beltrami، نويسنده , , Carlo Alberto and Di Loreto، نويسنده , , Carla، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
7
From page
97
To page
103
Abstract
The prognostic value of combined immunohistochemical analysis for the thyroid transcription factor-1 (TTF-1) and the proliferation marker MIB-1 was assessed in a consecutive series of non-small cell lung carcinomas (NSCLC). Tumor immunoreactivity for TTF-1 and MIB-1 was classified in three groups (−,+,++) and in two groups (−,+), respectively. Comparison across groups for TTF-1 reactivity showed significantly different survival curves (P=0.04). In particular, the best prognosis was associated with a TTF-1 negative pattern, whereas the TTF-1 ‘++’ cases showed the worst prognosis. A trend towards better prognosis was observed for MIB-1 negative cases (P=0.09). Multivariate analysis confirmed independent prognostic significance of TTF-1 (P=0.002), MIB-1 (P=0.01) and pStage (P=0.04). Accordingly, analysing TTF-1 and MIB-1 together, a better prediction of survival was obtained (P=0.02), with the poorest prognosis for the ‘TTF-1++/MIB-1+’ cases.
Keywords
Non-small cell lung carcinomas , Prognosis , thyroid transcription factor-1 , combined analysis , Survival analysis , MIB-1
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802040
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